Cytokine profile in community-acquired pneumonia in children

Community-acquired pneumonia (CAP) is one of the most common acute infectious diseases. To date, incidence CAP among children was decreased significantly worldwide, mainly due to increasing use effective preventive measures. Nevertheless, remains a cause childhood morbidity and mortality. Pneumonia may develop at any age, but often it occurs in young children, who are more likely have severe course pneumonia. Currently, early diagnosis prognosis disease severity an urgent issue. It found that, cases, panel conventional biomarkers, including number leukocytes, procalcitonin, CRP not sufficient for pediatric CAP. There demand new biological markers which, along with clinical evaluation, improve diagnostics management thus reducing risk adverse outcomes associated this disease. Such could be cytokines, which active participants pathogenesis. The aim study determine level several cytokines blood serum assess changes cytokine profile depending on patient’s age included 117 aged 1 18 years confirmed by X-ray examination. comparison group 28 healthy did or other signs respiratory viral infection time examination, being free chronic pathology requiring outpatient observation. A were determined quantitatively serum, i.e., IL-1β, IFNγ, IL-2, IL-4, IL-6, IL-10, TNFα, IFNλ2 (IL-28A), IFNλ3 (IL-28B), IL-8, MCP-1, IL-17AF, GM-CSF using test systems based “sandwich” method solid-phase ELISA peroxidase labeling. As result, that content higher community-acquired levels certain e.g., varied patients, thus, probably, reflecting degree immune system activation different groups.